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Euphorbia Factor L2

Euphorbia Factor L2
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Purity:99.89%
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Euphorbia Factor L2

Catalog No. T5798Cas No. 218916-51-9
Euphorbia Factor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation through inhibits NF-κB activation.
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Pack SizePriceAvailabilityQuantity
1 mg$68In Stock
5 mg$158In Stock
10 mg$228In Stock
25 mg$389In Stock
50 mg$572In Stock
100 mg$813In Stock
1 mL x 10 mM (in DMSO)$227In Stock
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Product Introduction

Bioactivity
Description
Euphorbia Factor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation through inhibits NF-κB activation.
In vivo
Euphorbia factor L2 (EFL2) on LPS-induced ALI in mice, where EFL2 attenuated pathological alterations in the lung and improved survival. Significant suppression of the recruitment and transmigration of inflammatory cells, specifically neutrophils, by 40?mg/kg of EFL2 was observed. EFL2 exerted potent anti-inflammatory effects by decreasing the levels of interleukin-1β (IL-1 β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF- α), interleukin-8 (IL-8) and myeloperoxidase (MPO) in the lung and bronchioalveolar lavage fluid. Consistent with the findings in vivo, EFL2 also showed robust inhibitory effects on the production of IL-1 β, IL-6, TNF- α and IL-8 released from LPS-stimulated RAW264.7 cells in vitro. Interestingly, this effect appeared to be mediated by EFL2's inhibition of NF-κB signaling activation, but not the MAPK pathway. Not only phosphorylation of IKK α/β and IκBα was down-regulated, p65 translocation and its DNA-binding activity were also significantly suppressed by EFL2. Moreover, overexpression of p65 reversed the inhibitory effect of EFL2 in LPS-induced NF-κB activation and cytokines production. The observed anti-inflammatory bioactivity of EFL2 indicates its potential as a drug development candidate, particularly for LPS-mediated disorders of inflammation[1].
Aliaseuphorbiafactor L2
Chemical Properties
Molecular Weight642.73
FormulaC38H42O9
Cas No.218916-51-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 12 mg/mL (18.67 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5559 mL7.7793 mL15.5586 mL77.7932 mL
5 mM0.3112 mL1.5559 mL3.1117 mL15.5586 mL
10 mM0.1556 mL0.7779 mL1.5559 mL7.7793 mL

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