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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $36 | In Stock | |
10 mg | $51 | In Stock | |
25 mg | $92 | In Stock | |
50 mg | $166 | In Stock | |
100 mg | $310 | In Stock | |
200 mg | $518 | In Stock | |
500 mg | $828 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer. |
In vitro | METHODS: Rat ventricular myocytes were treated with FCCP (10-1000 nM) for 1400 sec, and cellular oxygen consumption was measured using a Clark Oxygen Electrode. RESULTS: Oxygen consumption increased significantly, immediately, and in a dose-dependent manner after the addition of FCCP. [1] METHODS: Rat adrenal medullary chromaffinoma cells PC12 were treated with FCCP (30 µM) for 0.5-2 h. The rate of protein synthesis was measured using [3H]methionine. RESULTS: FCCP treatment produced a strong inhibition (68%) of protein synthesis rate for at least 2 hours. [2] |
In vivo | METHODS: To test the effect on stroke, FCCP (1 mg/kg) was injected intraperitoneally into a C57BL/6J mouse model of stroke, followed by one hour of transient middle cerebral artery occlusion (tMCAO). RESULTS: Infarct volumes in the cortex, striatum, and whole hemisphere were significantly increased in mice pretreated with FCCP. Mice receiving FCCP had significantly increased neurologic deficit scores compared to carriers. [3] METHODS: To assay anti-tumor activity in vivo, FCCP (1 mg/kg) and cisplatin (2 mg/kg) were intraperitoneally injected every two days for two weeks into C57BL/6 mice harboring mouse ovarian epithelial carcinoma tumor ID8. RESULTS: The combination of FCCP and cisplatin inhibited tumor growth via OMA1-induced mitochondrial and ER stress. [4] |
Cell Research | Protein synthesis rate is assayed in 24-mm diameter multi-well dishes with fresh medium containing 0.175 Ci/mmol of [3H]methionine (200 μM), for 30 min at 37°C. PC12 cells are treated with FCCP for different period of times. (Only for Reference) |
Alias | Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone, Trifluoromethoxy carbonylcyanide phenylhydrazone |
Molecular Weight | 254.17 |
Formula | C10H5F3N4O |
Cas No. | 370-86-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.54 mg/mL (9.99 mM), Working solution is recommended to be prepared and used immediately. DMSO: 55 mg/mL (216.39 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
10% DMSO+40% PEG300+5% Tween 80+45% Saline/DMSO
DMSO
|
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