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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $39 | In Stock | |
50 mg | $55 | In Stock | |
100 mg | $80 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. |
Targets&IC50 | CA I (human):1.044 μM (Ki), CA II (human):9.98 μM (Ki), CA II (human):17.5 μM (IC50), CA I (human):2.18 μM (IC50) |
In vitro | Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. [1] |
In vivo | Hourly topical administration of the drug suspension produces an average reduction of 46.8% in the polymorphonuclear leukocytes invading the corneal stroma. In the cornea, fluorometholone acetate appears to have a greater efficacy, as compared to fluorometholone alcohol, for reducing the number of leukocytes invading that tissue following an inflammatory stimulus. Animal toxicity studies of fluorometholone, including acute intraperitoneal LD50s in mice and rats, subacute oral toxicity in rats and dogs, and subacute topical ocular toxicity in rabbits have demonstrated the safety of this drug for human use. [2] |
Alias | NSC 47438, Flarex, Eflone, Oxylone acetate |
Molecular Weight | 418.5 |
Formula | C24H31FO5 |
Cas No. | 3801-06-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 84 mg/mL (200.71 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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