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FPL64176
🥰Excellent
Catalog No. T22788Cas No. 120934-96-5
Alias FPL 64176
FPL64176 is a L-type calcium channels activator.
FPL64176
🥰Excellent
Purity: 97.78%
Catalog No. T22788Alias FPL 64176Cas No. 120934-96-5
FPL64176 is a L-type calcium channels activator.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $36 | In Stock | |
| 5 mg | $80 | In Stock | |
| 10 mg | $128 | In Stock | |
| 25 mg | $278 | In Stock | |
| 50 mg | $513 | In Stock | |
| 100 mg | $747 | In Stock | |
| 500 mg | $1,560 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $94 | In Stock |
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Purity:97.78%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | FPL64176 is a L-type calcium channels activator. |
| In vitro | FPL-64176, on schistosomes cultured ex vivo and in an in vivo murine model of infection.?Unlike DHPs, FPL-64176 evokes rapid and sustained contractile paralysis of adult Schistosoma mansoni reminiscent of the anthelmintic praziquantel.?This is accompanied by tegument disruption and an arrest of mitotic activity in somatic stem cells and germ line tissues.?Interestingly, this strong ex vivo phenotype was temperature dependent, with FPL-64176 treatment being less potent at 37 C than 23 C. However, FPL-64176 caused intra-tegument lesions at the basement membrane of worms cultured ex vivo under both conditions,?as well as an in vivo hepatic shift of parasites from the mesenteric vasculature of infected mice to the liver[1]. |
| In vivo | Gene expression profiling of worms harvested following in vivo FPL-64176 exposure reveals differences in transcripts associated with muscle and extracellular matrix function, as well as female reproduction, which is consistent with the worm phenotypes observed following ex vivo drug treatment[1]. |
| Alias | FPL 64176 |
| Molecular Weight | 347.41 |
| Formula | C22H21NO3 |
| Cas No. | 120934-96-5 |
| Smiles | COC(=O)c1c(C)[nH]c(C)c1C(=O)c1ccccc1Cc1ccccc1 |
| Relative Density. | 1.174g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/ml (158.31 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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