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G3335 Acetate
🥰Excellent
Catalog No. T21598L
Alias G3335 Acetate (36099-95-3 free base)
G3335 Acetate was discovered to be a novel PPARgamma antagonist.
G3335 Acetate
🥰Excellent
Purity: 99.75%
Catalog No. T21598LAlias G3335 Acetate (36099-95-3 free base)
G3335 Acetate was discovered to be a novel PPARgamma antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $50 | In Stock | |
| 10 mg | $75 | In Stock | |
| 25 mg | $128 | In Stock | |
| 50 mg | $192 | In Stock | |
| 100 mg | $287 | In Stock | |
| 200 mg | $431 | In Stock | |
| 500 mg | $713 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $72 | In Stock |
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Purity:99.75%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | G3335 Acetate was discovered to be a novel PPARgamma antagonist. |
| Targets&IC50 | PPARγ:8.34 μM(kd), PPARγ:8.67 μM(kd) |
| In vitro | G3335 exhibits a highly specific binding affinity against PPARgamma (K(D) = 8.34 microM) and is able to block rosiglitazone, a potent PPARgamma agonist, in the stimulation of the interaction between the PPARgamma ligand-binding domain (LBD) and RXRalpha-LBD. Yeast two-hybrid assays demonstrated that G3335 exhibits strong antagonistic activity (IC50 = 8.67 microM) in perturbing rosiglitazone in the promotion of the PPARgamma-LBD-CBP interaction. |
| Alias | G3335 Acetate (36099-95-3 free base) |
| Molecular Weight | 393.39 |
| Formula | C18H23N3O7 |
| Smiles | OC(CC[C@H](NC([C@H](CC1=CNC2=C1C=CC=C2)N)=O)C(O)=O)=O.CC(O)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/ml (139.81 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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