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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $50 | In Stock | |
10 mg | $75 | In Stock | |
25 mg | $128 | In Stock | |
50 mg | $192 | In Stock | |
100 mg | $287 | In Stock | |
200 mg | $431 | In Stock | |
500 mg | $713 | In Stock | |
1 mL x 10 mM (in DMSO) | $72 | In Stock |
Description | G3335 Acetate was discovered to be a novel PPARgamma antagonist. |
In vitro | G3335 exhibits a highly specific binding affinity against PPARgamma (K(D) = 8.34 microM) and is able to block rosiglitazone, a potent PPARgamma agonist, in the stimulation of the interaction between the PPARgamma ligand-binding domain (LBD) and RXRalpha-LBD. Yeast two-hybrid assays demonstrated that G3335 exhibits strong antagonistic activity (IC50 = 8.67 microM) in perturbing rosiglitazone in the promotion of the PPARgamma-LBD-CBP interaction. |
Alias | G3335 Acetate (36099-95-3 free base) |
Molecular Weight | 393.39 |
Formula | C18H23N3O7 |
Cas No. |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/ml (139.81 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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