Shopping Cart

Remove All

Your shopping cart is currently empty

GS-829845

Select Batch

Purity:99.78%

Resource Download

COA HPLC HNMR

GS-829845

Catalog No. T67905Cas No. 1257705-09-1

GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life than the parent.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$57	In Stock
25 mg	$90	In Stock
50 mg	$128	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "GS-829845"

Product Introduction

Bioactivity

Description

GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life than the parent.

In vivo

Filgotinib did not alter metformin exposures, indicating that filgotinib and GS-829845 do not inhibit OCT2 and MATE1/2K at the clinical doses. Filgotinib was generally well-tolerated when administered alone or with the co-administered drugs in the studies. Results from these studies were the basis to enable the use of P-gp modulators and substrates of OCT2, MATE1, and MATE2K with filgotinib without the need for dose modifications in the current approved rheumatoid arthritis population.[2]

Chemical Properties

Molecular Weight	357.43
Formula	C17H19N5O2S
Cas No.	1257705-09-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (251.8 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7978 mL	13.9888 mL	27.9775 mL	139.8875 mL
5 mM	0.5596 mL	2.7978 mL	5.5955 mL	27.9775 mL
10 mM	0.2798 mL	1.3989 mL	2.7978 mL	13.9888 mL
20 mM	0.1399 mL	0.6994 mL	1.3989 mL	6.9944 mL
50 mM	0.0560 mL	0.2798 mL	0.5596 mL	2.7978 mL
100 mM	0.0280 mL	0.1399 mL	0.2798 mL	1.3989 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc