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GSK3186899

🥰Excellent
Catalog No. T15438Cas No. 1972617-87-0
Alias DDD-853651, 3,3,3-trifluoro-N-[4-[[3-[(2R)-2-methylmorpholin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]cyclohexyl]propane-1-sulfonamide

GSK3186899 is an inhibitor of Cdc2-related kinase 12 with an EC50 of 1.4 μM for L. donovani.

GSK3186899

GSK3186899

🥰Excellent
Purity: 98.35%
Catalog No. T15438Alias DDD-853651, 3,3,3-trifluoro-N-[4-[[3-[(2R)-2-methylmorpholin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]cyclohexyl]propane-1-sulfonamideCas No. 1972617-87-0
GSK3186899 is an inhibitor of Cdc2-related kinase 12 with an EC50 of 1.4 μM for L. donovani.
Pack SizePriceAvailabilityQuantity
1 mg$148In Stock
5 mg$323In Stock
10 mg$491In Stock
25 mg$833In Stock
50 mg$1,110In Stock
100 mg$1,450In Stock
200 mg$1,960In Stock
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Purity:98.35%
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Product Introduction

Bioactivity
Description
GSK3186899 is an inhibitor of Cdc2-related kinase 12 with an EC50 of 1.4 μM for L. donovani.
In vitro
GSK3186899 is active in cidal axenic amastigote assay with an EC50 value of 0.1 μM. GSK3186899 shows good selectivity against mammalian THP-1 host cells (EC50 value > 50 μM). GSK3186899 exhibits a less than 10-fold variation in potency against a panel of Leishmania-derived lines. GSK3186899 is more active using human peripheral blood mononuclear cells as the host cells[1].
In vivo
In the mouse model of infection, GSK3186899 (25 mg/kg; orally) reduces parasite levels by 99%. The efficacy of treatment is dependent on dose, frequency, and duration (10 days better than 5). There are no notable adverse effects in a rat seven-day repeat-dose oral toxicity study with respect to clinical chemistry and histopathology at all doses tested[1].
AliasDDD-853651, 3,3,3-trifluoro-N-[4-[[3-[(2R)-2-methylmorpholin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]cyclohexyl]propane-1-sulfonamide
Chemical Properties
Molecular Weight491.53
FormulaC19H28F3N7O3S
Cas No.1972617-87-0
SmilesC[C@H]1CN(CCO1)c1n[nH]c2nc(N[C@H]3CC[C@@H](CC3)NS(=O)(=O)CCC(F)(F)F)ncc12
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 200 mg/mL (406.89 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0345 mL10.1723 mL20.3446 mL101.7232 mL
5 mM0.4069 mL2.0345 mL4.0689 mL20.3446 mL
10 mM0.2034 mL1.0172 mL2.0345 mL10.1723 mL
20 mM0.1017 mL0.5086 mL1.0172 mL5.0862 mL
50 mM0.0407 mL0.2034 mL0.4069 mL2.0345 mL
100 mM0.0203 mL0.1017 mL0.2034 mL1.0172 mL

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