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GSK4112

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Purity:99.63%

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COA LCMS HPLC HNMR

GSK4112

Catalog No. T5045Cas No. 1216744-19-2

GSK4112 (SR6452) is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.

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Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$77	In Stock
25 mg	$163	In Stock
50 mg	$296	In Stock
100 mg	$531	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Product Introduction

Bioactivity

Description	GSK4112 (SR6452) is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
In vitro	GSK4112 profiled as a Rev-erb agonist in cells to inhibit expression of the circadian target gene bmal1. In addition, GSK4112 repressed the expression of gluconeogenic genes in liver cells and reduced glucose output in primary hepatocytes. Therefore, GSK4112 is useful as a chemical tool to probe the function of Rev-erb in transcriptional repression, regulation of circadian biology, and metabolic pathways. Additionally, GSK4112 may serve as a starting point for design of Rev-erb chemical probes with in vivo pharmacologicalm activity.
Alias	1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate, SR6452

Chemical Properties

Molecular Weight	396.89
Formula	C18H21ClN2O4S
Cas No.	1216744-19-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9.9 mg/mL(25 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5196 mL	12.5979 mL	25.1959 mL	125.9795 mL
5 mM	0.5039 mL	2.5196 mL	5.0392 mL	25.1959 mL
10 mM	0.2520 mL	1.2598 mL	2.5196 mL	12.5979 mL
20 mM	0.1260 mL	0.6299 mL	1.2598 mL	6.2990 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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