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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $45 | In Stock | |
25 mg | $83 | In Stock | |
50 mg | $134 | In Stock | |
100 mg | $239 | In Stock | |
1 mL x 10 mM (in DMSO) | $48 | In Stock |
Description | GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner. |
In vivo | In MIN6 cells, GW9508 stimulates insulin secretion in a dose-dependent manner and enhances insulin secretion mediated by KCl. In rat β-cells, GW9508 induces hyperpolarization and the opening of KATP channels. In HaCaT cells, GW9508 inhibits the expression of IL-11, IL-24, and IL-33 induced by TNF-α and IFN-γ. Additionally, in normal human epidermal keratinocytes, GW9508 suppresses the production of CCL5 and CXCL10. |
Alias | GW 9508 |
Molecular Weight | 347.41 |
Formula | C22H21NO3 |
Cas No. | 885101-89-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 34.7 mg/mL (100 mM) DMSO: 40 mg/mL (115.14 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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