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HBX 19818
🥰Excellent
Catalog No. T15464Cas No. 1426944-49-1
HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
HBX 19818
🥰Excellent
Purity: 98.76%
Catalog No. T15464Cas No. 1426944-49-1
HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $32 | In Stock | |
| 5 mg | $77 | In Stock | |
| 10 mg | $119 | In Stock | |
| 25 mg | $197 | In Stock | |
| 50 mg | $281 | In Stock | |
| 100 mg | $392 | In Stock | |
| 200 mg | $557 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $86 | In Stock |
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Purity:98.76%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM). |
| Targets&IC50 | USP7:28.1 μM |
| In vitro | HBX 19818 inhibits HCT116 proliferation in a dose-dependent manner (IC50: ～2 μM). HBX 19818 selectively inhibits USP7 (IC50: ～6 μM in human cancer cells). HBX 19818 (1.5, 4, 12, 36, or 100 μM) inhibits USP7 deubiquitination of polyubiquitinated p53. HBX 19818 displays no effects on USP8, USP5, USP10, CYLD, UCH-L1, UCH-L3, or on SENP1, a SUMO protease (IC50s of > 200 μM). HBX 19818 (30 μM) also causes significantly higher levels of Mdm2 polyubiquitinated forms in USP7-overproducing HEK293 cells than those in DMSO-treated control cells. |
| Molecular Weight | 421.96 |
| Formula | C25H28ClN3O |
| Cas No. | 1426944-49-1 |
| Smiles | CN(CCCNC(=O)c1ccc2nc3CCCCc3c(Cl)c2c1)Cc1ccccc1 |
| Relative Density. | 1.206 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (47.40 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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