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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $54 | In Stock | |
5 mg | $128 | In Stock | |
10 mg | $198 | In Stock | |
25 mg | $329 | In Stock | |
50 mg | $469 | In Stock | |
100 mg | $653 | In Stock | |
1 mL x 10 mM (in DMSO) | $143 | In Stock |
Description | HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM). |
In vitro | HBX 19818 inhibits HCT116 proliferation in a dose-dependent manner (IC50: ~2 μM). HBX 19818 selectively inhibits USP7 (IC50: ~6 μM in human cancer cells). HBX 19818 (1.5, 4, 12, 36, or 100 μM) inhibits USP7 deubiquitination of polyubiquitinated p53. HBX 19818 displays no effects on USP8, USP5, USP10, CYLD, UCH-L1, UCH-L3, or on SENP1, a SUMO protease (IC50s of > 200 μM). HBX 19818 (30 μM) also causes significantly higher levels of Mdm2 polyubiquitinated forms in USP7-overproducing HEK293 cells than those in DMSO-treated control cells. |
Molecular Weight | 421.96 |
Formula | C25H28ClN3O |
Cas No. | 1426944-49-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 20 mg/mL (47.40 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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