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HIV-1 TAT (48-60) Acetate
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Catalog No. T75964L
Alias HIV-1 TAT (48-60) Acetate(220408-24-2 Free base)
HIV-1 TAT (48-60) Acetate, a commonly used membrane-permeable carrier peptide, is an arginine-rich basic peptide derived from the human immunodeficiency virus (HIV-1 Tat) protein that enables intracellular delivery of compounds.
HIV-1 TAT (48-60) Acetate
🥰Excellent
Catalog No. T75964LAlias HIV-1 TAT (48-60) Acetate(220408-24-2 Free base)
HIV-1 TAT (48-60) Acetate, a commonly used membrane-permeable carrier peptide, is an arginine-rich basic peptide derived from the human immunodeficiency virus (HIV-1 Tat) protein that enables intracellular delivery of compounds.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $63 | In Stock | |
| 5 mg | $140 | In Stock | |
| 10 mg | $208 | In Stock | |
| 25 mg | $354 | In Stock | |
| 50 mg | $530 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | HIV-1 TAT (48-60) Acetate, a commonly used membrane-permeable carrier peptide, is an arginine-rich basic peptide derived from the human immunodeficiency virus (HIV-1 Tat) protein that enables intracellular delivery of compounds. |
| In vitro | Exogenous Tat proteins are able to activate the viral genome by penetrating the cell membrane and entering the nucleus.The HIV-1 TAT (48-60) Acetate peptide contains only the basic domain of the full-length peptide, but retains intact translocating activity, and at a standard dose of 1 mM is even more efficient at nuclear localization than other active peptides. [1] Cell-penetrating peptides are regarded as promising carriers for the delivery of large and hydrophilic molecules into cells. HIV-1 TAT (48-60) Acetate appeared to enter cells by endocytosis as observed by confocal laser scanning microscopy. [2] HIV-1 TAT (48-60) Acetate induces the formation of rod-like structures in DMPC, presumably inverted micelles, which may be intermediates as it crosses eukaryotic cell membranes. [3] |
| Alias | HIV-1 TAT (48-60) Acetate(220408-24-2 Free base) |
| Molecular Weight | 1779.07 |
| Formula | C72H135N35O18 |
| Smiles | O=C(N1[C@@H](CCC1)C(N[C@H](C(O)=O)CCC(N)=O)=O)[C@H]2N(CCC2)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC(CN)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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