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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $163 | In Stock | |
2 mg | $243 | In Stock | |
5 mg | $413 | In Stock | |
10 mg | $618 | In Stock | |
25 mg | $985 | In Stock | |
50 mg | $1,330 | In Stock |
Description | hSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer. |
In vitro | hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM and eliminates it at 1 μM in MDA 361 cells. It also inhibits MDA468 cell proliferation with an IC50 of 75 nM [1]. |
Molecular Weight | 566.07 |
Formula | C27H28ClN7O3S |
Cas No. | 1402452-15-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 70 mg/mL (123.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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