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hSMG-1 inhibitor 11j

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Purity:99.29%

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COA HNMR HPLC

hSMG-1 inhibitor 11j

Catalog No. T8884Cas No. 1402452-15-6

hSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer.

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Pack Size	Price	Availability
1 mg	$163	In Stock
2 mg	$243	In Stock
5 mg	$413	In Stock
10 mg	$618	In Stock
25 mg	$985	In Stock
50 mg	$1,330	In Stock

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Product Introduction

Bioactivity

Description	hSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer.
In vitro	hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM and eliminates it at 1 μM in MDA 361 cells. It also inhibits MDA468 cell proliferation with an IC50 of 75 nM [1].

Chemical Properties

Molecular Weight	566.07
Formula	C27H28ClN7O3S
Cas No.	1402452-15-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 70 mg/mL (123.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7666 mL	8.8328 mL	17.6657 mL	88.3283 mL
5 mM	0.3533 mL	1.7666 mL	3.5331 mL	17.6657 mL
10 mM	0.1767 mL	0.8833 mL	1.7666 mL	8.8328 mL
20 mM	0.0883 mL	0.4416 mL	0.8833 mL	4.4164 mL
50 mM	0.0353 mL	0.1767 mL	0.3533 mL	1.7666 mL
100 mM	0.0177 mL	0.0883 mL	0.1767 mL	0.8833 mL

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