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iFSP1

Catalog No. T11631 CAS 150651-39-1

iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RSL3. It uniquely triggers ferroptosis in GPX4-knockout cells overexpressing FSP1.

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iFSP1, CAS 150651-39-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 29.00
10 mg	In stock	$ 42.00
25 mg	In stock	$ 95.00
50 mg	In stock	$ 175.00
100 mg	In stock	$ 328.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.74%

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Description	iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RSL3. It uniquely triggers ferroptosis in GPX4-knockout cells overexpressing FSP1.
Targets&IC50	FSP1:103 nM (EC50)
In vitro	iFSP1 (0.001-1 μM; 24 hours) is less efficient than genetic deletion of FSP1, whereas iFSP1 treatment in the FSP1-knockout background had no additive effect to RSL3-induced ferroptosis.iFSP1 (3 μM; 24 hours) treatment results in an obvious toxicity of RSL3 in a panel of genetically engineered (FSP1-knockout) human cancer cell lines.AIFM2: the flavoprotein apoptosis-inducing factor mitochondria-associated 2 is a previously unrecognized anti-ferroptotic gene. AIFM2, which is renamed ferroptosis suppressor protein 1 (FSP1).iFSP1 (0.001-1 μM; 24 hours) inhibits the Gpx4-knockout cell growth as a dose-dependent manner, but does not inhibit the wild type cell growth. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4- knockout cells from iFSP1-induced ferroptosis.

Molecular Weight	323.35
Formula	C20H13N5
CAS No.	150651-39-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (77.32 mM), Sonication is recommended.

References and Literature

1. Doll S, et al. FSP1 is a glutathione-independent ferroptosis suppressor.Nature. 2019 Nov;575(7784):693-698.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Inhibitor Library Apoptosis Compound Library Cell Cycle Compound Library Anti-Cancer Compound Library Ferroptosis Compound Library Bioactive Compound Library

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Keywords

iFSP1 150651-39-1 Apoptosis Ferroptosis SW620 Gpx4-knockout FSP1 cancer FSP1-knockout iFSP-1 iFSP 1 cell U-373 A549 RSL3 NCl-H1437 inhibit Inhibitor inhibitor

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