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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $30 | In Stock | |
25 mg | $44 | In Stock | |
50 mg | $63 | In Stock | |
100 mg | $88 | In Stock | |
200 mg | $123 | In Stock | |
500 mg | $198 | In Stock | |
1 mL x 10 mM (in DMSO) | $63 | In Stock |
Description | Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent. |
Targets&IC50 | HMG-CoA reductase:8 nM |
In vitro | In a rabbit model, daily administration of Fluvastatin (10 mg/kg) significantly reversed the inhibition of acetylcholine-induced vasodilation, effectively reducing hyperlipidemia. |
In vivo | In human aortic smooth muscle cells, Fluvastatin (100 nM) reduces the formation of superoxide anion radicals activated by angiotensin II. In CHL/IU cells, Fluvastatin (8 μM) offers protection against DNA damage. It significantly inhibits the formation of thiobarbituric acid-reactive substances in lipid peroxidation initiated by divalent iron ions (IC50=12 μM). Fluvastatin (1-100 μM) can inhibit lipid peroxidation mediated by peroxyl radicals induced by 2,2'-azobis(2-amidinopropane) dihydrochloride and 2,2'-azobis. |
Alias | XU 62320 sodium, XU-62-320, Fluvastatin sodium salt |
Molecular Weight | 433.45 |
Formula | C24H25FNNaO4 |
Cas No. | 93957-55-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 10.8 mg/mL (25 mM) DMSO: 43.3 mg/mL (100 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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