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IPAG
🥰Excellent
Catalog No. T22870Cas No. 193527-91-2
IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis.
IPAG
🥰Excellent
Purity: 98.8%
Catalog No. T22870Cas No. 193527-91-2
IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 36 € | In Stock | |
| 5 mg | 84 € | In Stock | |
| 10 mg | 132 € | In Stock | |
| 25 mg | 264 € | In Stock | |
| 50 mg | 454 € | In Stock | |
| 100 mg | 654 € | In Stock |
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Purity:98.8%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis. |
| In vitro | IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass. IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1[2]. Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells[3]. |
| Molecular Weight | 395.28 |
| Formula | C17H22IN3 |
| Cas No. | 193527-91-2 |
| Smiles | Ic1ccc(NC(=N)NC2C3CC4CC(C3)CC2C4)cc1 |
| Relative Density. | 1.82 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 7.5 mg/mL (19.0 mM), when pH is adjusted to 3 with 1 M HCl. Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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