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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $38 | In Stock | |
5 mg | $89 | In Stock | |
10 mg | $139 | In Stock | |
25 mg | $278 | In Stock | |
50 mg | $478 | In Stock | |
100 mg | $689 | In Stock |
Description | IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis. |
In vitro | IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass. IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1[2]. Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells[3]. |
Molecular Weight | 395.28 |
Formula | C17H22IN3 |
Cas No. | 193527-91-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 7.5 mg/mL (19.0 mM), when pH is adjusted to 3 with 1 M HCl. Sonication and heating to 60℃ are recommended. Ethanol: 50 mMmg | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
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