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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $293 | In Stock | |
5 mg | $722 | In Stock | |
10 mg | $987 | In Stock | |
25 mg | $1,520 | In Stock | |
50 mg | $1,980 | In Stock | |
100 mg | $2,760 | In Stock |
Description | IPI-493 (17-amino17demethoxy) is a novel HSP90 inhibitor with antitumor activity. |
In vivo | In Nude mice of GIST-BOE, the oral doses of IPI-493 were 50 mg/kg twice daily, 40 mg/kg once daily, and 100 mg/kg three times weekly. In the GIST-PSW and GIST-48 models, the dose of IPI-493 was reduced to 80 mg/kg with no change in the duration of dosing.IPI-493 treatment resulted in tumor growth stabilization, different degrees of proliferation inhibition, induction of apoptosis and necrosis, and down-regulation of the KIT and its signaling cascade, especially in the GIST-BOE model.IPI-493 treatment significantly reduced vascular density.[5] |
Alias | 17-Aminodemethoxygeldanamycin, 17-Aminogeldanamycin, IPI 493, NSC 255109, 17-amino17demethoxy |
Molecular Weight | 545.62 |
Formula | C28H39N3O8 |
Cas No. | 64202-81-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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