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IPI-493
🥰Excellent
Catalog No. T32188Cas No. 64202-81-9
Alias NSC 255109, IPI 493, 17-Aminogeldanamycin, 17-Aminodemethoxygeldanamycin, 17-amino17demethoxy
IPI-493 (17-amino17demethoxy) is a novel HSP90 inhibitor with antitumor activity.
IPI-493
🥰Excellent
Purity: 100%
Catalog No. T32188Alias NSC 255109, IPI 493, 17-Aminogeldanamycin, 17-Aminodemethoxygeldanamycin, 17-amino17demethoxyCas No. 64202-81-9
IPI-493 (17-amino17demethoxy) is a novel HSP90 inhibitor with antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 278 € | In Stock | |
| 5 mg | 685 € | In Stock | |
| 10 mg | 937 € | In Stock | |
| 25 mg | 1.444 € | In Stock | |
| 50 mg | 1.881 € | In Stock | |
| 100 mg | 2.622 € | In Stock |
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Purity:100%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | IPI-493 (17-amino17demethoxy) is a novel HSP90 inhibitor with antitumor activity. |
| In vivo | In Nude mice of GIST-BOE, the oral doses of IPI-493 were 50 mg/kg twice daily, 40 mg/kg once daily, and 100 mg/kg three times weekly. In the GIST-PSW and GIST-48 models, the dose of IPI-493 was reduced to 80 mg/kg with no change in the duration of dosing.IPI-493 treatment resulted in tumor growth stabilization, different degrees of proliferation inhibition, induction of apoptosis and necrosis, and down-regulation of the KIT and its signaling cascade, especially in the GIST-BOE model.IPI-493 treatment significantly reduced vascular density.[5] |
| Alias | NSC 255109, IPI 493, 17-Aminogeldanamycin, 17-Aminodemethoxygeldanamycin, 17-amino17demethoxy |
| Molecular Weight | 545.62 |
| Formula | C28H39N3O8 |
| Cas No. | 64202-81-9 |
| Smiles | O=C(NC(C1=O)=CC2=O)/C(C)=C/C=C/[C@@H]([C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](CC1=C2N)C)OC)O)C)OC(N)=O)OC |
| Relative Density. | 1.25g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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