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IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $38 | In Stock | |
10 mg | $68 | In Stock | |
25 mg | $137 | In Stock | |
50 mg | $238 | In Stock | |
100 mg | $353 | In Stock | |
200 mg | $493 | In Stock | |
1 mL x 10 mM (in DMSO) | $42 | In Stock |
Description | IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. |
Targets&IC50 | HBx:2 nM(Kd) |
In vitro | IR415, at concentrations ranging from 50 to 200 μM, exhibits a dose-dependent inhibition of the Hepatitis B virus X protein (HBx), achieving its minimal effective concentration at 50 μM in the HepG2/GFP-shRNA line expressing HBx. HBx is identified as a suppressor of the host's defense mechanisms, specifically involved in the RNAi-based silencing of viral genes. |
Molecular Weight | 296.34 |
Formula | C13H14F2N4S |
Cas No. | 452967-14-5 |
Smiles | Fc1ccc(NC(=S)NCCCn2ccnc2)c(F)c1 |
Relative Density. | 1.32 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (421.81 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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