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IRAK4-IN-20
IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS).
Catalog No. T62714Cas No. 1931994-80-7
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Purity:97.32%
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IRAK4-IN-20
Catalog No. T62714Alias BAY-1834845Cas No. 1931994-80-7
IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS).
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $449 | In Stock | |
| 10 mg | $659 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS). |
| Targets&IC50 | IRAK4:3.55 nM |
| In vitro | Compound BAY-1834845 (IRAK4-IN-20) at a concentration of 500 nM, effectively reduces the secretion of inflammatory cytokines when administered for 20 hours in an in vitro assay involving LPS-stimulated human peripheral blood mononuclear cells (PBMC) [1]. |
| In vivo | IRAK4-IN-20 (Compound BAY-1834845), administered orally at 150 mg/kg either once 30 minutes before or twice at 4 and 12 hours after LPS induction, significantly mitigated acute respiratory distress syndrome in 6–7-week-old female Balb/c mice models. This treatment markedly reduced inflammatory cell and neutrophil infiltration in bronchoalveolar lavage fluid (BALF), decreased total T cells, monocytes, and macrophages, and preserved the integrity of naïve lymphocytes and stromal cells, including endothelial cells, chondrocytes, and smooth muscle cells. Moreover, it more effectively regulated inflammation and innate immunity genes compared to Dexamethasone, demonstrating its potential as a therapeutic agent for ARDS. |
| Alias | BAY-1834845 |
| Molecular Weight | 450.45 |
| Formula | C22H25F3N4O3 |
| Cas No. | 1931994-80-7 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (55.5 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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