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JNJ 303

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Purity:98.33%

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COA HPLC HNMR

JNJ 303

Catalog No. T7653Cas No. 878489-28-2

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).

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Pack Size	Price	Availability
1 mg	$41	In Stock
2 mg	$59	In Stock
5 mg	$91	In Stock
10 mg	$150	In Stock
25 mg	$343	In Stock
50 mg	$497	In Stock
100 mg	$742	In Stock
1 mL x 10 mM (in DMSO)	$93	In Stock

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Questions

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Product Introduction

Bioactivity

Description

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).

In vitro

Optical mapping was used to measure action potential durations (APDs) in the presence of the IKs blocker JNJ-303 and the IKr blocker E-4031.?JNJ-303 alone did not increase APD.?However, under isoprenaline (ISO), both the application of JNJ-303 and additional E-4031 significantly increased APD.?With JNJ-303, ISO decreased APD significantly more in the epicardium as compared to the endocardium, with subsequent application E-4031 increasing mid- and endocardial APD80 more significantly than in the epicardium.?We found that β-AR stimulation significantly augmented the effect of IKs blocker JNJ-303, in contrast to the reduced effect of IKr blocker E-4031[1].

Chemical Properties

Molecular Weight	440.98
Formula	C21H29ClN2O4S
Cas No.	878489-28-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (24.94 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2677 mL	11.3384 mL	22.6768 mL	113.3838 mL
5 mM	0.4535 mL	2.2677 mL	4.5354 mL	22.6768 mL
10 mM	0.2268 mL	1.1338 mL	2.2677 mL	11.3384 mL
20 mM	0.1134 mL	0.5669 mL	1.1338 mL	5.6692 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc