Shopping Cart
- Remove All
Your shopping cart is currently empty
JNJ-1661010
🥰Excellent
Catalog No. T2684Cas No. 681136-29-8
Alias Takeda-25, JNJ1661010, JNJ 1661010
JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
JNJ-1661010
🥰Excellent
Purity: 99.97%
Catalog No. T2684Alias Takeda-25, JNJ1661010, JNJ 1661010Cas No. 681136-29-8
JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $39 | In Stock | |
| 25 mg | $86 | In Stock | |
| 50 mg | $137 | In Stock | |
| 100 mg | $245 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "JNJ-1661010"
2-Chlorophenylboronic acid
T775133900-89-8
2-Chlorophenylboronic acid is a monohalogenated phenylboronic acid, which is an important pharmaceutical intermediate and is widely used in the synthesis of new drugs.2-Chlorophenylboronic acid has an inhibitory effect on fatty acid amidase with a Ki value of 0.01-1 µM, and is used in the study of depression, glaucoma, neuropathic pain, anxiety, migraine, I diabetes and gastritis. , migraine, type I diabetes and gastritis.
- $50
Size
QTY
Carprofen
Rimadyl, Ridamyl, Imadyl
T132553716-49-7
Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.
- $36
Size
QTY
PF 750
ZINC27647189, UNII-7756CPP14K, PF-750
T16515959151-50-9
PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.
- $33
Size
QTY
WWL 154
WWL-154
T89271338574-93-8
WWL 154 is an serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4 inhibitor.
- $38
Size
QTY
Dual FAAH/sEH-IN-1
T635362756099-59-7In house
Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity and anti-inflammatory activity.
- $143
Size
QTY
VU534
T77594923509-20-0
VU534 is a NAPE-PLD agonist with an EC50 of 0.30 μM.VU534 is a dual inhibitor of FAAH and sEH, with an IC50 of 1.2 μM for sEH.VU534 is used in diseases related to cardiometabolism.
- $36
Size
QTY
FAAH inhibitor 1
Benzothiazole analog 3
T11256326866-17-5
FAAH inhibitor 1 (Benzothiazole analog 3) is a potent FAAH inhibitor with an IC50 of 18 nM.
- $48
Size
QTY
PDP-EA
T28353861891-72-7
PDP-EA is an activator of fatty acid amide hydrolase(FAAH) and enhances the amidohydrolase activity of FAAH.
- $29
Size
QTY
Biochanin A
Cited
Olmelin, 4-Methylgenistein
T2859491-80-5
Biochanin A (4-Methylgenistein) is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. Biochanin A is a naturally occurring fatty acid amide hydrolase (FAAH) inhibitor.
- $30
Size
QTY
CitedJNJ-42165279
JNJ42165279
T32151346528-50-4
JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 receptors, enzymes, transporters, and
- $38
Size
QTY
AA38-3
1-Piperidinecarboxylic acid, 4-nitrophenyl ester
T937465815-76-1
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)
- $38
Size
QTY
Select Batch
Purity:99.97%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2. |
| Targets&IC50 | FAAH (rat):10 nM, FAAH (human):12 nM |
| In vitro | Preincubation of JNJ-1661010 with fatty acid amide hydrolase showed a slow reversible interaction between JNJ-1661010 and the active site, which was catalyzed by high temperature. In the hydrophobic channel, JNJ-1661010 could dock with phenylthiadiazole, and in the hydrophilic pocket of fatty acid amide hydrolase, it docked with phenylurea. |
| In vivo | Preincubation of JNJ-1661010 with fatty acid amide hydrolase showed a slow reversible interaction between JNJ-1661010 and the active site, which was catalyzed by high temperature. In the hydrophobic channel, JNJ-1661010 could dock with phenylthiadiazole, and in the hydrophilic pocket of fatty acid amide hydrolase, it docked with phenylurea. |
| Alias | Takeda-25, JNJ1661010, JNJ 1661010 |
| Molecular Weight | 365.45 |
| Formula | C19H19N5OS |
| Cas No. | 681136-29-8 |
| Smiles | O=C(Nc1ccccc1)N1CCN(CC1)c1nc(ns1)-c1ccccc1 |
| Relative Density. | 1.340 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 3.7 mg/mL (10 mM) DMSO: 36.6 mg/mL (100 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
| |||||||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy JNJ-1661010 | purchase JNJ-1661010 | JNJ-1661010 cost | order JNJ-1661010 | JNJ-1661010 chemical structure | JNJ-1661010 in vivo | JNJ-1661010 in vitro | JNJ-1661010 formula | JNJ-1661010 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.