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JNJ-1661010
Catalog No. T2684Cas No. 681136-29-8
Alias Takeda-25, JNJ1661010, JNJ 1661010
JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
JNJ-1661010
Catalog No. T2684Alias Takeda-25, JNJ1661010, JNJ 1661010Cas No. 681136-29-8
JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $39 | In Stock | |
| 25 mg | $86 | In Stock | |
| 50 mg | $137 | In Stock | |
| 100 mg | $245 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Purity:99.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2. |
| Targets&IC50 | FAAH (rat):10 nM, FAAH (human):12 nM |
| In vitro | Preincubation of JNJ-1661010 with fatty acid amide hydrolase showed a slow reversible interaction between JNJ-1661010 and the active site, which was catalyzed by high temperature. In the hydrophobic channel, JNJ-1661010 could dock with phenylthiadiazole, and in the hydrophilic pocket of fatty acid amide hydrolase, it docked with phenylurea. |
| In vivo | Preincubation of JNJ-1661010 with fatty acid amide hydrolase showed a slow reversible interaction between JNJ-1661010 and the active site, which was catalyzed by high temperature. In the hydrophobic channel, JNJ-1661010 could dock with phenylthiadiazole, and in the hydrophilic pocket of fatty acid amide hydrolase, it docked with phenylurea. |
| Alias | Takeda-25, JNJ1661010, JNJ 1661010 |
| Molecular Weight | 365.45 |
| Formula | C19H19N5OS |
| Cas No. | 681136-29-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 3.7 mg/mL (10 mM) DMSO: 36.6 mg/mL (100 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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