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JNJ-17203212

JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).

Catalog No. T7526Cas No. 821768-06-3

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Purity:99.94%

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COA HNMR HPLC

JNJ-17203212

Catalog No. T7526Cas No. 821768-06-3

JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$64	In Stock
10 mg	$113	In Stock
25 mg	$263	In Stock
50 mg	$428	In Stock
100 mg	$690	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock

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Product Introduction

Bioactivity

Description	JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
Targets&IC50	TRPV1 (rat):102 nM, TRPV1 (human):65 nM
In vivo	TRPV1 antagonist, JNJ-17203212, reduces sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity.??TRPV1 is involved in the pathogenesis of visceral hypersensitivity and that JNJ-17203212 may be a potential therapeutic agent for functional bowel disorders characterized by abdominal hypersensitivity, such as irritable bowel syndrome[1].
Animal Research	Colonic sensitivity was assessed via quantification of VMR to CRD in rats following a single, oral administration of JNJ-17203212 (3, 10 or 30 mg/kg) or vehicle[1].

Chemical Properties

Molecular Weight	419.32
Formula	C₁₇H₁₅F₆N₅O
Cas No.	821768-06-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (238.48 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3848 mL	11.9241 mL	23.8481 mL	119.2407 mL
5 mM	0.4770 mL	2.3848 mL	4.7696 mL	23.8481 mL
10 mM	0.2385 mL	1.1924 mL	2.3848 mL	11.9241 mL
20 mM	0.1192 mL	0.5962 mL	1.1924 mL	5.9620 mL
50 mM	0.0477 mL	0.2385 mL	0.4770 mL	2.3848 mL
100 mM	0.0238 mL	0.1192 mL	0.2385 mL	1.1924 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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