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JNJ-64619178

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Purity:99.63%

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COA HNMR HPLC

JNJ-64619178

Catalog No. T15624Cas No. 2086772-26-9

JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.

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Pack Size	Price	Availability
1 mg	$79	In Stock
5 mg	$178	In Stock
10 mg	$262	In Stock
25 mg	$439	In Stock
50 mg	$648	In Stock
1 mL x 10 mM (in DMSO)	$192	In Stock

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Product Introduction

Bioactivity

Description	JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.
In vitro	JNJ-64619178 displays effective and broad inhibition of cellular growth. JNJ-64619178 binds simultaneously to the S-adenosylmethionine (SAM)- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action [1].
In vivo	In several non-small cell lung cancer and small cell lung cancer mouse xenograft models, JNJ-64619178 (p.o.) causes efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery and direct substrates of the methylosome [1].

Chemical Properties

Molecular Weight	483.36
Formula	C22H23BrN6O2
Cas No.	2086772-26-9

Storage & Solubility Information

Storage

store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (248.26 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0689 mL	10.3443 mL	20.6885 mL	103.4426 mL
5 mM	0.4138 mL	2.0689 mL	4.1377 mL	20.6885 mL
10 mM	0.2069 mL	1.0344 mL	2.0689 mL	10.3443 mL
20 mM	0.1034 mL	0.5172 mL	1.0344 mL	5.1721 mL
50 mM	0.0414 mL	0.2069 mL	0.4138 mL	2.0689 mL
100 mM	0.0207 mL	0.1034 mL	0.2069 mL	1.0344 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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