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KR-32568

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Purity:99.89%

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COA HNMR HPLC

KR-32568

Catalog No. T36569Cas No. 852146-73-7

KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM). KR-32568 exhibits potent cardioprotective effects. When used at a concentration of 10 μM, it restored cardiac systolic function in an isolated ischemic rat heart model. KR-32568 (0.3 mg/kg) reduced the size of myocardial infarction in a rat model of ischemia and reperfusion injury.

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Pack Size	Price	Availability
1 mg	$64	In Stock
5 mg	$155	In Stock
10 mg	$247	In Stock
25 mg	$497	In Stock
50 mg	$723	In Stock
100 mg	$987	In Stock
500 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$145	In Stock

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Product Introduction

Bioactivity

Description	KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM). KR-32568 exhibits potent cardioprotective effects. When used at a concentration of 10 μM, it restored cardiac systolic function in an isolated ischemic rat heart model. KR-32568 (0.3 mg/kg) reduced the size of myocardial infarction in a rat model of ischemia and reperfusion injury.
In vitro	KR-32568 (10 nM-1 μM) inhibited NHE-1-mediated platelet swelling induced by intracellular acidification in rabbit platelet-rich plasma in a concentration-dependent manner with an IC50 value of 24 nM.[1]
In vivo	KR-32568 (0.1-1.0 mg/kg; i.v.; once) exerts effective cardioprotective effects in rats, such as reducing infarct size and significantly reducing the total number of premature ventricular contractions.[1]

Chemical Properties

Molecular Weight	261.25
Formula	C13H12FN3O2
Cas No.	852146-73-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (344.5 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8278 mL	19.1388 mL	38.2775 mL	191.3876 mL
5 mM	0.7656 mL	3.8278 mL	7.6555 mL	38.2775 mL
10 mM	0.3828 mL	1.9139 mL	3.8278 mL	19.1388 mL
20 mM	0.1914 mL	0.9569 mL	1.9139 mL	9.5694 mL
50 mM	0.0766 mL	0.3828 mL	0.7656 mL	3.8278 mL
100 mM	0.0383 mL	0.1914 mL	0.3828 mL	1.9139 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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