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LCS3

Catalog No. T60446Cas No. 109844-92-0

LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 μM and 3.8 μM, respectively. LCS3 has antitumour activity, induces apoptosis and can be used in the study of lung adenocarcinoma (LUAD).

LCS3

LCS3

Purity: 99.68%
Catalog No. T60446Cas No. 109844-92-0
LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 μM and 3.8 μM, respectively. LCS3 has antitumour activity, induces apoptosis and can be used in the study of lung adenocarcinoma (LUAD).
Pack SizePriceAvailabilityQuantity
1 mg$51In Stock
5 mg$122In Stock
10 mg$197In Stock
25 mg$455In Stock
50 mg$672In Stock
100 mg$956In Stock
500 mg$1,920In Stock
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Purity:99.68%
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Product Introduction

Bioactivity
Description
LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 μM and 3.8 μM, respectively. LCS3 has antitumour activity, induces apoptosis and can be used in the study of lung adenocarcinoma (LUAD).
Targets&IC50
GSR:3.3 µM, TXNRD1:3.8 µM, M. tuberculosis:0.098 µM(MIC)
In vitro
LCS3 (5 nM-10 µM ; 96 h) effectively inhibits lung cancer cell lines, while non-transformed lung cells show no signs of inhibition.[1]
LCS3 (3 µM ; 3, 6, and 12 h) induces ROS and NRF2 pathway activation in sensitive lung adenocarcinoma (LUAD) cells.[1]
LCS3 (3 µM ; 96 h) selectively kills lung adenocarcinoma (LUAD) cell lines, in part through the induction of apoptosis.[1]
Chemical Properties
Molecular Weight266.64
FormulaC11H7ClN2O4
Cas No.109844-92-0
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 112.5 mg/mL (421.9 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7504 mL18.7519 mL37.5038 mL187.5188 mL
5 mM0.7501 mL3.7504 mL7.5008 mL37.5038 mL
10 mM0.3750 mL1.8752 mL3.7504 mL18.7519 mL
20 mM0.1875 mL0.9376 mL1.8752 mL9.3759 mL
50 mM0.0750 mL0.3750 mL0.7501 mL3.7504 mL
100 mM0.0375 mL0.1875 mL0.3750 mL1.8752 mL

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