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Lodenafil

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Purity:98%

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COA HNMR

Lodenafil

Catalog No. T7346Cas No. 139755-85-4

Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)

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Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$77	In Stock
10 mg	$123	In Stock
25 mg	$218	In Stock
50 mg	$326	In Stock
100 mg	$455	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock

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Product Introduction

Bioactivity

Description	Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)
In vivo	Investigated right ventricular hypertrophy (RVH) and IL-1 levels in lung fragments. The number of cases of RVH was significantly higher in the monocrotaline group than in the lodenafil and control groups, as were mPAP and IL-1 levels. Lodenafil can prevent monocrotaline-induced PH, RVH, and inflammation[1].
Animal Research	Thirty male Sprague-Dawley rats were randomly divided into three groups: control; monocrotaline (experimental model); and lodenafil (experimental model followed by lodenafil treatment, 5 mg/kg daily for 28 days) Mean pulmonary artery pressure (mPAP) was obtained by right heart catheterization[1].
Alias	Hydroxyhomosildenafil

Chemical Properties

Molecular Weight	504.6
Formula	C23H32N6O5S
Cas No.	139755-85-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (495.44 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9818 mL	9.9088 mL	19.8177 mL	99.0884 mL
5 mM	0.3964 mL	1.9818 mL	3.9635 mL	19.8177 mL
10 mM	0.1982 mL	0.9909 mL	1.9818 mL	9.9088 mL
20 mM	0.0991 mL	0.4954 mL	0.9909 mL	4.9544 mL
50 mM	0.0396 mL	0.1982 mL	0.3964 mL	1.9818 mL
100 mM	0.0198 mL	0.0991 mL	0.1982 mL	0.9909 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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