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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $35 | In Stock | |
5 mg | $81 | In Stock | |
10 mg | $129 | In Stock | |
25 mg | $278 | In Stock | |
50 mg | $455 | In Stock | |
100 mg | $655 | In Stock | |
500 mg | $1,360 | In Stock |
Description | LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM. |
Targets&IC50 | mGlu1:0.145 μM, EGFR:0.91 μM |
In vitro | LY456236 (2 μM; 30 min) reduces the proliferation of DHPG-stimulated OCCM-30 cells.[1] |
In vivo | LY456236 exhibits anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once).[2] |
Alias | MPMQ hydrochloride |
Molecular Weight | 317.77 |
Formula | C16H16ClN3O2 |
Cas No. | 338736-46-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 225.0 mg/mL (708.1 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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