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Mavelertinib
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Mavelertinib
Catalog No. T21322Cas No. 1776112-90-3
Mavelertinib (PF-06747775) is an orally available, selective and potent EGFR tyrosine kinase (EGFR TKI) inhibitor with inhibitory effects on T790M/L858R and T790M/Del, and can be used in the study of oncology and respiratory diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $83 | In Stock | |
| 2 mg | $118 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $319 | In Stock | |
| 25 mg | $542 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $226 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Mavelertinib (PF-06747775) is an orally available, selective and potent EGFR tyrosine kinase (EGFR TKI) inhibitor with inhibitory effects on T790M/L858R and T790M/Del, and can be used in the study of oncology and respiratory diseases. |
| In vitro | Inhibiting the hERG26 current with an IC50 greater than 100 μM, Mavelertinib exhibits selectivity over wild-type EGFR (IC50=307 nM)[1]. With less than 50% effect or inhibition against all nonkinase targets at 10 μM, Mavelertinib demonstrates its selectivity[1]. |
| In vivo | Following oral administration (1 mg/kg to mouse, rat, and dog), Mavelertinib exhibits low to moderate oral bioavailability (mouse 60%, rat 11%, dog 66%)[1]. Due to moderate to high plasma clearance (mouse 53, rat 49, dog 12 mL/min/kg) and low steady-state volume of distribution (mouse 1.48, rat 0.66, dog 0.94 L/kg), Mavelertinib exhibits short plasma half-lives (mouse 0.56, rat 0.28, dog 1.3 h) following intravenous administration[1]. |
| Alias | PF 06747775, PFE-X775, PF-06747775, PF-7775, PF 6747775, PF6747775 |
| Molecular Weight | 415.42 |
| Formula | C18H22FN9O2 |
| Cas No. | 1776112-90-3 |
| Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
| Solubility Information | DMSO: 30 mg/mL (72.22 mM) H2O: <0.1 mg/mL | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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