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Merafloxacin
🥰Excellent
Catalog No. T9066Cas No. 91188-00-0
Alias CI 934
Merafloxacin (CI 934) is a fluoroquinolone antibacterial, which was also identified as a 1 PRF inhibitor of SARS-CoV-2.
Merafloxacin
🥰Excellent
Purity: 97.57%
Catalog No. T9066Alias CI 934Cas No. 91188-00-0
Merafloxacin (CI 934) is a fluoroquinolone antibacterial, which was also identified as a 1 PRF inhibitor of SARS-CoV-2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $56 | In Stock | |
| 2 mg | $79 | In Stock | |
| 5 mg | $122 | In Stock | |
| 10 mg | $198 | In Stock | |
| 25 mg | $363 | In Stock | |
| 50 mg | $539 | In Stock | |
| 100 mg | $778 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $133 | In Stock |
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Purity:97.57%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Merafloxacin (CI 934) is a fluoroquinolone antibacterial, which was also identified as a 1 PRF inhibitor of SARS-CoV-2. |
| Targets&IC50 | SARS-CoV-2:19.6 μM (IC50) |
| In vitro | Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on -1 PRF of other beta coronaviruses.?Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting -1 PRF as an effective antiviral strategy for SARS-CoV-2. |
| Alias | CI 934 |
| Molecular Weight | 379.4 |
| Formula | C19H23F2N3O3 |
| Cas No. | 91188-00-0 |
| Smiles | CCNCC1CCN(C1)c1c(F)cc2c(c1F)n(CC)cc(C(O)=O)c2=O |
| Relative Density. | 1.304 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble)  H2O: Insoluble |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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