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ML-60218

ML-60218
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Purity:98.1%
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ML-60218

Catalog No. T40661Cas No. 577784-91-9
ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and hampers the formation of new viroplasms.
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Pack SizePriceAvailabilityQuantity
1 mg$51In Stock
2 mg$74In Stock
5 mg$122In Stock
10 mg$197In Stock
25 mg$455In Stock
50 mg$672In Stock
100 mg$956In Stock
1 mL x 10 mM (in DMSO)$133In Stock
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Product Introduction

Bioactivity
Description
ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and hampers the formation of new viroplasms.
In vitro
ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest. The combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis[1]. ML-60218 interferes with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage[2].
Chemical Properties
Molecular Weight452.38
FormulaC19H15Cl2N3O2S2
Cas No.577784-91-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 95 mg/mL (210.00 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2105 mL11.0527 mL22.1053 mL110.5265 mL
5 mM0.4421 mL2.2105 mL4.4211 mL22.1053 mL
10 mM0.2211 mL1.1053 mL2.2105 mL11.0527 mL
20 mM0.1105 mL0.5526 mL1.1053 mL5.5263 mL
50 mM0.0442 mL0.2211 mL0.4421 mL2.2105 mL
100 mM0.0221 mL0.1105 mL0.2211 mL1.1053 mL

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