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ML133 hydrochloride
🥰Excellent
Catalog No. T6592Cas No. 1222781-70-5
Alias ML133 HCl
ML133 hydrochloride (ML133 HCl) is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.
ML133 hydrochloride
🥰Excellent
Purity: 99.48%
Catalog No. T6592Alias ML133 HClCas No. 1222781-70-5
ML133 hydrochloride (ML133 HCl) is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $43 | In Stock | |
| 10 mg | $61 | In Stock | |
| 25 mg | $108 | In Stock | |
| 50 mg | $173 | In Stock | |
| 100 mg | $288 | In Stock | |
| 200 mg | $373 | In Stock | |
| 500 mg | $629 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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Purity:99.48%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ML133 hydrochloride (ML133 HCl) is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1. |
| Targets&IC50 | KIR2.1 (pH 8.5):290 nM, KIR2.1 (pH 7.4):1.8 μM |
| In vitro | The ratio of total concentration of extracellular ML133 versus intracellular ML133 is 1:0.13 at pH 6.5, 1:9.09 at pH 8.5. ML133 is clean against 3A4 and 2C9 (IC50 >30 μM), displays moderate inhibition of 1A2 (IC50 = 3.3 μM) but proves to be a potent inhibitor of 2D6 (IC50 = 0.13 μM) in CYP450 assay. ML133 is highly protein bound (>99%) in both human and rat and also displays high intrinsic clearance in both species. ML133 (10 μM) is not displaced by K+ influx from the wild-type Kir2.1 in HEK 293 cells. M1 and/or M2 transmembrane domains contain the critical molecular determinant for ML133 inhibition of Kir2.1, especially D172 and I176. [1] |
| Alias | ML133 HCl |
| Molecular Weight | 313.82 |
| Formula | C19H19NO·HCl |
| Cas No. | 1222781-70-5 |
| Smiles | Cl.COC1=CC=C(CNCC2=CC=CC3=CC=CC=C23)C=C1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 16.67 mg/mL (53.11 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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