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MM3122

Catalog No. T60085 CAS 2574390-27-3

Synonyms: GTPL11533, MM-3122, Ac-GQFR-kbt

MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MM3122, CAS 2574390-27-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 83.00
2 mg	In stock	$ 119.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 319.00
25 mg	In stock	$ 597.00
50 mg	In stock	$ 866.00
100 mg	In stock	$ 1,160.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
In vitro	MM3122 (0-1 μM) has inhibitory activity against HGFA, matriptase, hepsin and thrombin with the IC50 values of 32, 0.31, 0.19 and more than 20 nM, respectively. MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, MERS VSV pseudotype calu-3 and VSV-SARS CoV-2 chimera calu-3 with the EC50 values of 74, 0.87 nM and 0.43 respectively [1].
In vivo	MM3122, administered intraperitoneally (i.p.) at doses ranging from 0-100 mg/kg daily for 7 days, showed no adverse effects, including no weight loss or changes in harvested organs (liver, spleen, and kidney), when compared to control subjects. Additionally, a single i.p. dose of MM3122 at 16.7 mg/kg was found to have a plasma half-life of 8.6 hours and a lung half-life of 7.5 hours in NSG mice[1].

Synonyms	GTPL11533, MM-3122, Ac-GQFR-kbt
Molecular Weight	665.76
Formula	C31H39N9O6S
CAS No.	2574390-27-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (135.2 mM), Sonification is recommended.

References and Literature

1. Matthew Mahoney, et al. A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2108728118.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Viral Compound Library

Related Products

Related compounds with same targets

GRL0617 CDD-1845 Molnupiravir SARS-CoV-2-IN-50 SARS-CoV-2-IN-42 MTase-IN-1 Dihydrotanshinone I Arbemnifosbuvir

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MM3122 2574390-27-3 Microbiology/Virology SARS-CoV GTPL11533 GTPL-11533 GTPL 11533 MM 3122 MM-3122 Ac-GQFR-kbt inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.