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MMPIP hydrochloride

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Catalog No. T23008LCas No. 1215566-78-1
Alias MMPIP hydrochloride (479077-02-6 Free base)

MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions.

MMPIP hydrochloride

MMPIP hydrochloride

🥰Excellent
Purity: 99.26%
Catalog No. T23008LAlias MMPIP hydrochloride (479077-02-6 Free base)Cas No. 1215566-78-1
MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions.
Pack SizePriceAvailabilityQuantity
1 mg$54In Stock
2 mg$79In Stock
5 mg$128In Stock
10 mg$213In Stock
25 mg$438In Stock
50 mg$649In Stock
100 mg$926In Stock
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Purity:99.26%
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Product Introduction

Bioactivity
Description
MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions.
In vitro
In CHO cells coexpressing rat mGluR7 with Gα15, MMPIP hydrochloride inhibits L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; 0.5 mM)-induced intracellular Ca2+ mobilization with an IC50 of 26 nM. MMPIP hydrochloride also antagonizes L-AP4-induced inhibition of cAMP accumulation with an IC50 of 610 nM. MMPIP hydrochloride inhibits L-AP4-induced inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing rat mGluR7[1].
In vivo
MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. MMPIP hydrochloride (10 mg/kg; i.p.) rescues the MK-801 (0.1 mg/kg)-induced cognitive impairments, by improving the choice accuracy. MMPIP hydrochloride (10 mg/kg) attenuates the amplitude of the acoustic startle response and markedly enhances the prepulse-induced inhibition of the acoustic startle response (up to 137% of control)[2].
AliasMMPIP hydrochloride (479077-02-6 Free base)
Chemical Properties
Molecular Weight369.8
FormulaC19H16ClN3O3
Cas No.1215566-78-1
SmilesCl.COc1ccc(cc1)-c1cc2onc(-c3ccncc3)c2c(=O)n1C
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 3.7 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7042 mL13.5208 mL27.0416 mL135.2082 mL
5 mM0.5408 mL2.7042 mL5.4083 mL27.0416 mL
10 mM0.2704 mL1.3521 mL2.7042 mL13.5208 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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