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Bofutrelvir

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Purity:100%

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COA HNMR HPLC

Bofutrelvir

Catalog No. T37173Cas No. 2103278-86-8

Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.

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Pack Size	Price	Availability
1 mg	$198	In Stock
5 mg	$572	In Stock
10 mg	$813	In Stock
25 mg	$1,190	In Stock
50 mg	$1,630	In Stock
100 mg	$2,180	In Stock

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Product Introduction

Bioactivity

Description	Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.
In vitro	MPro Inhibitor 11a (24 hours) exhibits in vitro inhibitory activity against SARS-CoV-2 and its variants when combined with remdesivir treatment[1].
In vivo	In K18-hACE2 mice infected with the SARS-CoV-2 Delta variant, MPro Inhibitor 11a (100 and 200 mg/kg; intraperitoneal injection; administered once daily at 100 and 200 mg/kg on day 0 and twice daily on days 1, 2, and 3 for 4 consecutive days) demonstrated a dose-dependent efficacy against lung viral titers, effectively reducing lung viral loads[2].
Alias	DC-402234, MPro Inhibitor 11a, FB2001

Chemical Properties

Molecular Weight	452.55
Formula	C25H32N4O4
Cas No.	2103278-86-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 30 mg/mL

DMF: 30 mg/mL

DMSO: 80 mg/mL (176.78 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2097 mL	11.0485 mL	22.0970 mL	110.4850 mL
5 mM	0.4419 mL	2.2097 mL	4.4194 mL	22.0970 mL
10 mM	0.2210 mL	1.1049 mL	2.2097 mL	11.0485 mL
20 mM	0.1105 mL	0.5524 mL	1.1049 mL	5.5243 mL
50 mM	0.0442 mL	0.2210 mL	0.4419 mL	2.2097 mL
100 mM	0.0221 mL	0.1105 mL	0.2210 mL	1.1049 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc