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mTOR inhibitor-8

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Purity:98.11%

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COA HPLC HNMR

mTOR inhibitor-8

Catalog No. T36316Cas No. 2489196-70-3

mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer.

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Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$247	In Stock
10 mg	$396	In Stock
25 mg	$728	In Stock
50 mg	$987	In Stock
100 mg	$1,390	In Stock
500 mg	$2,780	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Product Introduction

Bioactivity

Description	mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer.
In vitro	mTOR inhibitor-8 (Compound 5e; 0.1-10 μM) suppresses the growth of A549 cells in a dose-dependent manner after 24 and 48 hours of treatment[1]. mTOR inhibitor-8 induces autophagy in an mTOR-dependent manner. At a concentration of 10 μM, mTOR inhibitor-8 induces autophagy in a time-dependent manner (3-24 hours), leading to enhanced levels of LC3B-II[1].At a concentration of 10 μM for 3-24 hours, mTOR inhibitor-8 reduces the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1), two essential substrates of mTOR[1].
In vivo	In vivo, mTOR inhibitor-8 effectively inhibits tumor growth at concentrations of 25 and 50 μM for a duration of 6 days, without adversely affecting angiogenesis in the normal chick chorioallantoic membrane [1].
Alias	mTOR-IN-8

Chemical Properties

Molecular Weight	446.95
Formula	C24H19ClN4OS
Cas No.	2489196-70-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (44.75 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2374 mL	11.1869 mL	22.3739 mL	111.8693 mL
5 mM	0.4475 mL	2.2374 mL	4.4748 mL	22.3739 mL
10 mM	0.2237 mL	1.1187 mL	2.2374 mL	11.1869 mL
20 mM	0.1119 mL	0.5593 mL	1.1187 mL	5.5935 mL

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