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NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $113 | In Stock | |
2 mg | $166 | In Stock | |
5 mg | $278 | In Stock | |
10 mg | $455 | In Stock | |
25 mg | $787 | In Stock | |
50 mg | $1,160 | In Stock | |
100 mg | $1,620 | In Stock | |
1 mL x 10 mM (in DMSO) | $297 | In Stock |
Description | NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively. |
In vitro | NCGC00029283 (0-100 μM; 24-72 h) effectively inhibits cell proliferation in U2-OS cells[1]. |
Molecular Weight | 337.3 |
Formula | C18H12FN3O3 |
Cas No. | 714240-31-0 |
Smiles | COc1ccc2[nH]c(=O)c(cc2c1)-c1noc(n1)-c1ccc(F)cc1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 6.3 mg/mL (18.7 mM), Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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