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NCGC00029283

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Catalog No. T40823Cas No. 714240-31-0

NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively.

NCGC00029283

NCGC00029283

🥰Excellent
Purity: 99.6%
Catalog No. T40823Cas No. 714240-31-0
NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively.
Pack SizePriceAvailabilityQuantity
1 mg$113In Stock
2 mg$166In Stock
5 mg$278In Stock
10 mg$455In Stock
25 mg$787In Stock
50 mg$1,160In Stock
100 mg$1,620In Stock
1 mL x 10 mM (in DMSO)$297In Stock
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Purity:99.6%
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Product Introduction

Bioactivity
Description
NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively.
In vitro
NCGC00029283 (0-100 μM; 24-72 h) effectively inhibits cell proliferation in U2-OS cells[1].
Chemical Properties
Molecular Weight337.3
FormulaC18H12FN3O3
Cas No.714240-31-0
SmilesCOc1ccc2[nH]c(=O)c(cc2c1)-c1noc(n1)-c1ccc(F)cc1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 6.3 mg/mL (18.7 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9647 mL14.8236 mL29.6472 mL148.2360 mL
5 mM0.5929 mL2.9647 mL5.9294 mL29.6472 mL
10 mM0.2965 mL1.4824 mL2.9647 mL14.8236 mL

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