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Nesbuvir

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Catalog No. TQ0090Cas No. 691852-58-1
Alias HCV-796

Nesbuvir is a selective hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent polymerase inhibitor.Nesbuvir has an IC50 of 9 nM against hepatocellular carcinoma cells containing 1b HCV replicons.

Nesbuvir

Nesbuvir

🥰Excellent
Purity: 98.72%
Catalog No. TQ0090Alias HCV-796Cas No. 691852-58-1
Nesbuvir is a selective hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent polymerase inhibitor.Nesbuvir has an IC50 of 9 nM against hepatocellular carcinoma cells containing 1b HCV replicons.
Pack SizePriceAvailabilityQuantity
1 mg$97In Stock
5 mg$239In Stock
10 mg$322In Stock
25 mg$558In Stock
50 mg$818In Stock
100 mg$1,070In Stock
500 mg$2,150In Stock
1 mL x 10 mM (in DMSO)$263In Stock
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Purity:98.72%
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Product Introduction

Bioactivity
Description
Nesbuvir is a selective hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent polymerase inhibitor.Nesbuvir has an IC50 of 9 nM against hepatocellular carcinoma cells containing 1b HCV replicons.
Targets&IC50
NS5B:5 nM, NS3V170A:13 nM (EC50), NS3V170A:9 nM (EC50), NS5BI424V:13 nM (EC50), NS3K583T:15 nM (EC50)
In vitro
Nesbuvir (40 or 80 nM) (approximately 10 and 20 times the EC50 in a 3-day replicon inhibition assay, respectively). The EC50 for Nesbuvir in the transient expression assay is 14 nM, whereas it is 5 nM for the stable replicon.[1]
Nesbuvir (0.1 and 1 μM; Huh-7 cells; for 16 days) reduced about 3.6 log10 and 4.2 log10 HCV RNA levels, respectively.[3]
In vivo
Nesbuvir is demonstrated to yield significant antiviral effects in mice with chimeric human livers and in patients infected with HCV.[2]
Nesbuvir (chimeric mouse model) treatment resulted in a 2.02 +/- 0.55 log reduction in HCV titer, whereas in combination with interferon using a suboptimal dose of 30 mg/kg three times per day showed a 2.44 log reduction and were better than interferon treatment only.[5]
Cell Research
Huh7-BB7 cells are seeded at a density of 20,000 cells per 100 mm dish in DMEM supplemented with 2% FBS, 1 mg/mL G418, and various concentrations of Nesbuvir and/or Boceprevir with DMSO at a final concentration of 0.5% (vol/vol). The medium is removed and is replaced with a fresh medium with the appropriate compound concentrations every 3 or 4 days. After 7 days, the cells are split 1 to 10, placed into fresh 100 mm dishes, and incubated with medium with the appropriate compound concentrations. After 20 days, the medium is removed and the cells are fixed with 7% (wt/vol) formaldehyde and stained with 1% (wt/vol) crystal violet in 50% (vol/vol) ethanol [1].
AliasHCV-796
Chemical Properties
Molecular Weight446.49
FormulaC22H23FN2O5S
Cas No.691852-58-1
SmilesCNC(=O)c1c(oc2cc(N(CCO)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Relative Density.1.407 g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45.0 mg/mL (100.8 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2397 mL11.1985 mL22.3969 mL111.9846 mL
5 mM0.4479 mL2.2397 mL4.4794 mL22.3969 mL
10 mM0.2240 mL1.1198 mL2.2397 mL11.1985 mL
20 mM0.1120 mL0.5599 mL1.1198 mL5.5992 mL
50 mM0.0448 mL0.2240 mL0.4479 mL2.2397 mL
100 mM0.0224 mL0.1120 mL0.2240 mL1.1198 mL

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