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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $78 | 35 days | |
5 mg | $215 | 35 days | |
10 mg | $383 | 35 days | |
25 mg | $763 | 35 days |
Description | Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 μM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflammation. |
Molecular Weight | 300.31 |
Formula | C15H16N4O3 |
Cas No. | 331949-35-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: 30 mg/mL Ethanol: 15 mg/mL |
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