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NH-3
Catalog No. T40548Cas No. 447415-26-1
NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
NH-3
Catalog No. T40548Cas No. 447415-26-1
NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $229 | In Stock | |
| 5 mg | $578 | In Stock | |
| 10 mg | $833 | In Stock | |
| 25 mg | $1,270 | In Stock | |
| 50 mg | $1,690 | In Stock | |
| 100 mg | $2,290 | In Stock | |
| 500 mg | $4,620 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $518 | In Stock |
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Purity:97.09%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment. |
| Targets&IC50 | THR:55 nM (IC50) |
| In vivo | Administration of NH3 (46.2-27,700 nmol/kg/day; 7 days) modestly reduces heart rate beginning at a dose of 46.2 nmol/kg/day, with this effect dissipating at doses exceeding 2920 nmol/kg/day. NH3 does not influence the cholesterol-reducing properties of T3 at 46.2 nmol/kg/day. However, it does obstruct the increase in heart rate and suppression of TSH caused by T3 up to a dosage of 924 nmol/kg/day [2]. |
| Molecular Weight | 473.52 |
| Formula | C28H27NO6 |
| Cas No. | 447415-26-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 95 mg/mL (200.63 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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