Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 229.00 | |
5 mg | In stock | $ 578.00 | |
10 mg | In stock | $ 833.00 | |
25 mg | In stock | $ 1,270.00 | |
50 mg | In stock | $ 1,690.00 | |
100 mg | In stock | $ 2,290.00 | |
500 mg | In stock | $ 4,620.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 518.00 |
Description | NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment. |
Targets&IC50 | THR:55 nM (IC50) |
In vivo | Administration of NH3 (46.2-27,700 nmol/kg/day; 7 days) modestly reduces heart rate beginning at a dose of 46.2 nmol/kg/day, with this effect dissipating at doses exceeding 2920 nmol/kg/day. NH3 does not influence the cholesterol-reducing properties of T3 at 46.2 nmol/kg/day. However, it does obstruct the increase in heart rate and suppression of TSH caused by T3 up to a dosage of 924 nmol/kg/day [2]. |
Molecular Weight | 473.52 |
Formula | C28H27NO6 |
CAS No. | 447415-26-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (200.63 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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NH-3 447415-26-1 Endocrinology/Hormones Thyroid hormone receptor(THR) Inhibitor NH 3 orally thyromi-metic inhibit GC-1 recruitment Thyroid Hormone Receptor THR NH3 cofactor inhibitor