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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $39 | In Stock | |
10 mg | $59 | In Stock | |
25 mg | $98 | In Stock | |
50 mg | $143 | In Stock | |
100 mg | $213 | In Stock | |
1 mL x 10 mM (in DMSO) | $48 | In Stock |
Description | NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprotective activity against NMDA-induced hippocampal neuronal cell death and mitochondrial dysfunction. NMDAR/TRPM4-IN-2 showed neuroprotective activity against NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons with an IC50 value of 2.1 μM. |
In vitro | NMDAR/TRPM4-IN-2, also referred to as compound 8 within the concentration range of 0-10 μM, interrupts the interactions between GluN2A and GluN2B with TRPM4 in a dose-dependent fashion. Through its action, it abolishes the CREB shutdown pathway, concurrently reactivating the ERK1/2 pathway and stimulating IEG induction, while preserving the NMDARs' inherent ability to drive synaptic activity-led transcription enhancement. |
Molecular Weight | 330.092 |
Formula | C11H19BrCl2N2 |
Cas No. | 2243506-33-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 112.5 mg/mL (340.8 mM), Sonication is recommended. H2O: 90.0 mg/mL (272.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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