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Nodosin has an anti-inflammatory function via inhibition of IL-2. Nodosin perfusion provides a potential protective effect by inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transplantation.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $116 | In Stock | |
5 mg | $241 | In Stock | |
10 mg | $357 | In Stock | |
1 mL x 10 mM (in DMSO) | $287 | In Stock |
Description | Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transplantation. |
In vitro | In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin.METHODS AND RESULTS: In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, the cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum. |
Molecular Weight | 362.42 |
Formula | C20H26O6 |
Cas No. | 10391-09-0 |
Smiles | [H][C@]12[C@H](O)OC[C@@]11[C@]([H])(CCC2(C)C)OC(=O)[C@@]23C[C@@H](C[C@@H](O)[C@@]12[H])C(=C)C3=O |
Relative Density. | 1.37 g/cm3 (Predicted) |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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