diterpenoid

Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.

Sculponeatin A is a natural product from Rabdosia amethystoides.

Eurycomanol 2-O-β-D-glucopyranoside, a natural diterpenoid compound, is extracted from Tongkat Ali.

Rosthornin A is a kind of natural product derived from the herbs of Rabdosia rosthornii.

Maoecrystal B is a diterpenoid isolated from the leaves of Isodon eriocalyx var.

Trichorabdal A shows a very strong in vitro antibacterial activity against Helicobacter pylori.

Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.

Kamebanin, a natural diterpenoid, has antibacterial activity. It also shows efficient cytotoxic activity against HeLa and HL-60 cells.

Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.

1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treatment of neurodegenerative diseases such as arthritis.

7β-Hydroxylathyrol is a diterpenoid extract from the seed oil of Caper Spurge and displays P-gp inhibition resulting in cytotoxic properties.

1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.

Rosthornin B is a kind of natural product derived from the herbs of Rabdosia rosthornii.

Pseudolaric Acid C2 is a diterpenoid isolated from Pseudolarix kaempferi.

9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory effect of the pine needles and may play an important role in the allelopathy of red pine.

Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.

Kauran-16,17-diol, a natural diterpenoid product, exhibits anti-tumoral and apoptosis-inducing activities by inhibiting NO production in LPS-induced RAW 264.7 cells with an IC50 value of 17 μM.

Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia reperfusion injury in liver transplantation.

Asebotoxin III is a diterpenoid obtained from the leaves of Asebi, Pieris japonica.

Triptonoterpene Me ether (compound 5), a rosinane-type diterpenoid, is derived from the traditional Chinese medicinal plant, Tripterygium wilfordii Hook. f [1].

Salvifaricin, an orally active diterpenoid isolated from Salvia leucantha Cav. and Salvia hispanica L., significantly lowers fasting blood glucose and serum triglyceride (TG) levels, exhibiting an anti-diabetic effect [1] [2].

Euphoscopin C, a diterpenoid isolated from Euphorbia helioscopia, significantly enhances the cytotoxic activity of natural killer (NK) cells against H1299-luci and A549-luci cells [1].

Carmichasine B, a natural diterpenoid alkaloid, can be isolated from Aconitum carmichaelii [1].

Aconicarchamine B, a C20-diterpenoid alkaloid, is isolated from Aconitum carmichaelii [1].

1-Oxomicrostegiol, a diterpenoid extracted from the roots of Salvia viridis L. cvar, serves as a direct precursor to viroxocin [1].

Kansuinine E, a jatrophane-type diterpenoid, is a plant-derived compound isolated from the roots of E. kansui. It functions as a nitric oxide inhibitor, with an inhibitory concentration of 6.3 μM (IC50).

Inflexuside B, an abietane diterpenoid derived from the aerial parts of Isodon inflexus, effectively inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages [1].

Salviandulin E, a diterpenoid isolated from Salvia leucantha CAV., exhibits antitrypanosomal activity against T. b. brucei GUTat 3.1 parasites, demonstrating an IC50 value of 0.72 µg/mL [1] [2].

Triptonoterpene is a natural product found in Tripterygium wilfordii and Tripterygium doianum. Triptonoterpene is an abietane diterpenoid.

Rabdosin A is a diterpenoid antitumor constituent from Rabdosia japonica.

Wulfenioidin H (Compound 5), a diterpenoid, demonstrates anti-Zika virus (ZIKV) activity by inhibiting the expression of the ZIKV envelope (E) protein, resulting in an effective concentration \( EC_{50} \) value of 8.50 μM [1].

Xerophilusin A, an ent-kaurane diterpenoid, is extractable from the aerial parts of Isodon enanderianus [1].

Salvileucantholide, a diterpenoid extracted from Salvia leucantha [1], exhibits noteworthy pharmacological properties.

Euphorblin R (EOF2), a rhamnyl diterpenoid extracted from Euphorbia resinifera, has been shown to enhance lysosomal biogenesis, suggesting its utility in researching lysosome-associated diseases.

6,7-Dihydrosalviandulin E, a neo-clerodane diterpenoid, can be isolated from the aerial parts of Salvia leucantha, also known as Salvileucalin A. [1]

Rabdoserrin A is a diterpenoid with antifungal activity [1][2].

Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).

Clerodendrin is a New Neoclerodane Diterpenoid.

Epirosmanol is a diterpenoid containing a lactone moiety. Epirosmanol is a very weakly basic (essentially neutral) compound (based on its pKa).

Zeylasterone, a diterpenoid, is present in the plant Celastrus paniculatus [1].

Triptonoditerpenic acid is an aromatic pimarane diterpenoid that can be isolated from Tripterygium wilfordii. It exhibits cytotoxicity against HepG2, Hep3B, and Bcap37 cell lines, with IC50 values of 42.53 μM, 29.74 μM, and 37.63 μM, respectively.

Genkwadaphnin, a daphnane diterpenoid, targets importin-β1, reducing the nuclear accumulation of CRPC drivers and suppressing downstream oncogenic signaling. Demonstrating potent anti-tumor effects, it inhibits castration-resistant prostate cancer (CRPC) in vivo in mice [1].

Euphoheliosnoid A (Compound 24), a diterpenoid, significantly enhances natural killer (NK) cell-mediated cytotoxicity against H1299-luci cells and A549-luci cells at a concentration of 2.5 μM [1].

Dugesin C, a diterpenoid extracted from Salvia dugesii, showcases a spiro carbocyclic ring system originating from the standard neocrotane skeleton [1].

Epinodosinol, a diterpenoid isolated from the plant Rabdosia angustifolia, exhibits inhibitory activity against specific cancer cell lines [1].

Delcorine, a C19-diterpenoid alkaloid, is isolated from the entire herb of Delphinium anthriscifolium var. savatieri [1].

2-Isopropyl-8,8-dimethyl-7,8-dihydrophenanthrene-3,4,5(6H)-trione, a C20-norabietane diterpenoid with anti-inflammatory properties, is isolated from sage leaves [1].

Viroxocin, a diterpenoid, is isolated from the roots of Salvia viridis L. cvar. Blue Jeans and exhibits weak antibacterial activity [1].

Ranaconitine is an important diterpenoid alkaloid from Aconitum sinomontanum Nakai,ranaconitine has cardiotoxicity.

Hypaconine, a C19-diterpenoid alkaloid isolated from Aconitum and Delphinium spp., exhibits strong cardiac activity.