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NS13001

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Purity:99.55%

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COA HPLC HNMR

NS13001

Catalog No. T16345Cas No. 1063331-94-1

NS13001 (N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine) is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.

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Pack Size	Price	Availability
2 mg	$45	In Stock
5 mg	$98	In Stock
10 mg	$179	In Stock
25 mg	$322	In Stock
50 mg	$455	In Stock
100 mg	$655	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Product Introduction

Bioactivity

Description

Alias

N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine, N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine

Chemical Properties

Molecular Weight	353.81
Formula	C17H16ClN7
Cas No.	1063331-94-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (254.37 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8264 mL	14.1319 mL	28.2638 mL	141.3188 mL
5 mM	0.5653 mL	2.8264 mL	5.6528 mL	28.2638 mL
10 mM	0.2826 mL	1.4132 mL	2.8264 mL	14.1319 mL
20 mM	0.1413 mL	0.7066 mL	1.4132 mL	7.0659 mL
50 mM	0.0565 mL	0.2826 mL	0.5653 mL	2.8264 mL
100 mM	0.0283 mL	0.1413 mL	0.2826 mL	1.4132 mL

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