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Nucleozin

Nucleozin
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Purity:98%
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Nucleozin

Catalog No. T7330Cas No. 341001-38-5
Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication.
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Pack SizePriceAvailabilityQuantity
2 mg$36In Stock
5 mg$53In Stock
10 mg$85In Stock
25 mg$178In Stock
50 mg$289In Stock
100 mg$428In Stock
1 mL x 10 mM (in DMSO)$62In Stock
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Product Introduction

Bioactivity
Description
Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication.
In vitro
Nucleozin blocked the cytoplasmic trafficking of ribonucleoproteins (RNPs) that had undergone nuclear export, promoting the formation of large perinuclear aggregates of RNPs along with cellular Rab11. This effect led to the production of much reduced amounts of often markedly smaller virus particles. The primary target of nucleozin is the viral RNP. IAV replication can be effectively inhibited by blocking cytoplasmic trafficking of the viral genome[1].
In vivo
Nucleozin, that triggers the aggregation of NP and inhibits its nuclear accumulation. Nucleozin impeded influenza A virus replication in vitro with a nanomolar median effective concentration (EC(50)) and protected mice challenged with lethal doses of avian influenza A H5N1. Viral NP is a valid target for the development of small-molecule therapies[2].
Cell Research
For live imaging, cells were grown in chambered glass bottom dishes and maintained at 37°C in L-15 CO2-independent medium (Gibco) during analysis. Cells were transfected with GFP-NP and infected with PR8 12 h later. For nucleozin treatment, images were acquired for 5 min and then nucleozin was added to a final concentration of 2 μM before imaging for around 20 to 30 min . Images were acquired at 0.25 or 0.71 frame/s and processed with ImageJ[1].
Chemical Properties
Molecular Weight426.85
FormulaC21H19ClN4O4
Cas No.341001-38-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 28.66 mg/mL (67.14 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3427 mL11.7137 mL23.4274 mL117.1372 mL
5 mM0.4685 mL2.3427 mL4.6855 mL23.4274 mL
10 mM0.2343 mL1.1714 mL2.3427 mL11.7137 mL
20 mM0.1171 mL0.5857 mL1.1714 mL5.8569 mL
50 mM0.0469 mL0.2343 mL0.4685 mL2.3427 mL

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