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ONO-8130
🥰Excellent
Catalog No. T21976Cas No. 459841-96-4
ONO-8130 is an orally available antagonist of EP1 receptor.
ONO-8130
🥰Excellent
Purity: 97.82%
Catalog No. T21976Cas No. 459841-96-4
ONO-8130 is an orally available antagonist of EP1 receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $162 | In Stock | |
| 5 mg | $360 | In Stock | |
| 10 mg | $593 | In Stock | |
| 25 mg | $948 | In Stock | |
| 50 mg | $1,290 | In Stock |
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Purity:97.82%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ONO-8130 is an orally available antagonist of EP1 receptor. |
| In vivo | Oral preadministration of ONO-8130 at 0.3-30 mg/kg strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner, but had slight effect on the increased bladder weight and vascular permeability.?Oral ONO-8130 at 30 mg/kg also reversed the established cystitis-related bladder pain.?Intravesical administration of prostaglandin E2 caused prompt phosphorylation of ERK in the L6 spinal cord, an effect blocked by ONO-8130.?The prostaglandin E2/EP1 system participates in processing of cystitis-related bladder pain, and that EP1 antagonists including ONO-8130 are useful for treatment of bladder pain, particularly in interstitial cystitis.?Prostaglandin E2 contributes to cystitis-related bladder pain via EP1 receptors in mice, indicating possible therapeutic usefulness of selective EP1 antagonists[1]. |
| Molecular Weight | 500.63 |
| Formula | C25H28N2O5S2 |
| Cas No. | 459841-96-4 |
| Smiles | N(S(=O)(=O)C=1SC=C(C)N1)(CC(C)C)C2=C(OCC3=CC=C(C(O)=O)C=C3)C=C4C(=C2)CCC4 |
| Relative Density. | 1.344 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (10 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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