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PAOPA
🥰Excellent
Catalog No. T23121Cas No. 114200-31-6
PAOPA is a novel dopamine D2 receptor modulator and L-proline-L-leucine-glycine amide (PLG) peptide mimetic that prevents and reverses behavioral and biochemical abnormalities in preclinical animal models of schizophrenia sensitized to amphetamine. PAOPA has been used in the study of schizophrenia and extrapyramidal dysfunction.
PAOPA
🥰Excellent
Purity: 100%
Catalog No. T23121Cas No. 114200-31-6
PAOPA is a novel dopamine D2 receptor modulator and L-proline-L-leucine-glycine amide (PLG) peptide mimetic that prevents and reverses behavioral and biochemical abnormalities in preclinical animal models of schizophrenia sensitized to amphetamine. PAOPA has been used in the study of schizophrenia and extrapyramidal dysfunction.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $2,120 | In Stock | |
| 50 mg | $2,780 | In Stock | |
| 100 mg | $3,700 | In Stock |
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Purity:100%
ee:99.84%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PAOPA is a novel dopamine D2 receptor modulator and L-proline-L-leucine-glycine amide (PLG) peptide mimetic that prevents and reverses behavioral and biochemical abnormalities in preclinical animal models of schizophrenia sensitized to amphetamine. PAOPA has been used in the study of schizophrenia and extrapyramidal dysfunction. |
| In vitro | 10 μM PAOPA, treated for 1.5 hr increased striatal expression of GRK2 in D2/eYFP-labeled cells and promoted expression of arrestin-3, phosphorylated ERK1 and ERK2. 10 μM PAOPA, treated for 48 h then promoted internalization of D2 receptors in D2/eYFP-labeled cells. [1] |
| In vivo | In chronic administration, intraperitoneal injection of 1 mg/kg PAOPA once daily for 45 days enhanced D2 receptor modulation and up-regulated the expression of downstream molecules (e.g., GRK2, arrestin-3, and phosphorylated ERK 1/2) in mice. [1] |
| Molecular Weight | 254.29 |
| Formula | C11H18N4O3 |
| Cas No. | 114200-31-6 |
| Smiles | N(C(=O)[C@@H]1CCCN1)[C@H]2C(=O)N(CC(N)=O)CC2 |
| Relative Density. | 1.33 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (39.33 mM), Sonication is recommended. H2O: <25.43 mg/mL | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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