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Lufotrelvir

Lufotrelvir
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Purity:100%
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Lufotrelvir

Catalog No. T9574Cas No. 2468015-78-1
Lufotrelvir (PF-07304814) is a small molecule inhibitor of the SARS CoV-2 3CL protease for the treatment of COVID-19 with broad-spectrum anti-SARS activity for the study of novel coronavirus infections.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$68In Stock
2 mg$98In Stock
5 mg$163In Stock
10 mg$278In Stock
25 mg$563In Stock
50 mg$959In Stock
100 mg$1,450In Stock
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Product Introduction

Bioactivity
Description
Lufotrelvir (PF-07304814) is a small molecule inhibitor of the SARS CoV-2 3CL protease for the treatment of COVID-19 with broad-spectrum anti-SARS activity for the study of novel coronavirus infections.
In vivo
After intravenous administration to rats, dogs, and monkeys, Lufotrelvir exhibits favorable cardiovascular safety and pharmacokinetic parameters[1].
AliasPF-07304814
Chemical Properties
Molecular Weight552.51
FormulaC24H33N4O9P
Cas No.2468015-78-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (180.99 mM), Sonification is recommended.
H2O: 30 mg/mL (54.30 mM), Sonification is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.8099 mL9.0496 mL18.0992 mL90.4961 mL
5 mM0.3620 mL1.8099 mL3.6198 mL18.0992 mL
10 mM0.1810 mL0.9050 mL1.8099 mL9.0496 mL
20 mM0.0905 mL0.4525 mL0.9050 mL4.5248 mL
50 mM0.0362 mL0.1810 mL0.3620 mL1.8099 mL
DMSO
1mg5mg10mg50mg
100 mM0.0181 mL0.0905 mL0.1810 mL0.9050 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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