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PHY34
🥰Excellent
Catalog No. T37376Cas No. 2130033-55-3
PHY34 is a late stage autophagy inhibitor with nanomolar level inhibitory effect and anti-tumor activity against high-grade serous ovarian cancer (HGSOC) in vivo.
PHY34
🥰Excellent
Purity: 98.32%
Catalog No. T37376Cas No. 2130033-55-3
PHY34 is a late stage autophagy inhibitor with nanomolar level inhibitory effect and anti-tumor activity against high-grade serous ovarian cancer (HGSOC) in vivo.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $167 | In Stock | |
| 2 mg | $248 | In Stock | |
| 5 mg | $389 | In Stock | |
| 10 mg | $577 | In Stock | |
| 25 mg | $926 | In Stock | |
| 50 mg | $1,260 | In Stock | |
| 100 mg | $1,680 | In Stock | |
| 500 mg | $3,380 | In Stock |
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Purity:98.32%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PHY34 is a late stage autophagy inhibitor with nanomolar level inhibitory effect and anti-tumor activity against high-grade serous ovarian cancer (HGSOC) in vivo. |
| In vitro | In HGSOC cell lines, PHY34 showed cytotoxicity with IC50 of 4 nM. Its IC50 values in MDA-MB-435 and MDAMB-231 cell lines were 23 nM and 5.2 nM, respectively. In OVCAR3 cells, 100 nM PHY34 increased the level of early and late apoptotic cells [1]. |
| In vivo | In the hollow fiber deflector, PHY34 significantly inhibited the growth of cancer cells; In the transplanted tumor model, PHY34 reduced the ovarian tumor load. The bioavailability of mice was 56.6% after intravenous injection of 0.6 mg/kg, intraperitoneal injection of 1.8 mg/kg or oral administration of 75 mg/kg PHY34, and 2.5% after oral administration. After oral administration, the systemic clearance (CL) was 194.1 L/hr/kg, which was nearly 40 times the liver blood flow of mice, indicating that PHY34 had significant extrahepatic clearance. After oral administration, PHY34 was rapidly absorbed, and Tmax was 0.25 hr [1]. |
| Molecular Weight | 582.55 |
| Formula | C30H30O12 |
| Cas No. | 2130033-55-3 |
| Smiles | O=C1C2=C(C=3C(C(O[C@H]4[C@H](O)[C@@]5([C@]([C@@H](CO)O4)(OC(C)(C)O5)[H])[H])=C2CO1)=CC(OC)=C(OC)C3)C=6C=C7C(=CC6)OCO7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMF: 30 mg/mL (51.5 mM), Sonication is recommended. DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL (0.43 mM), Sonication is recommended. DMSO: 90 mg/mL (154.49 mM), Sonication is recommended. Ethanol: 10 mg/mL (17.17 mM), Sonication is recommended. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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