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physalin F

Catalog No. T8716 CAS 57423-71-9

Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection

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physalin F, CAS 57423-71-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 45.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 129.00
25 mg	In stock	$ 219.00
50 mg	In stock	$ 326.00
100 mg	In stock	$ 485.00
1 mL * 10 mM (in DMSO)	In stock	$ 122.00

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Purity: 99.61%

Purity: 99.07%

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Storage & Solubility Information

Description	Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection
In vivo	Physalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities.?A concentration-dependent inhibition of spontaneous proliferation of PBMC from HAM/TSP subjects was observed in the presence of physalin F, as evaluated by (3)H-thymidine uptake.?The IC50 for physalin F was 0.97 0.11 μM.?Flow cytometry analysis using Cytometric Bead Array (CBA) showed that physalin F (10 μM) significantly reduced the levels of IL-2, IL-6, IL-10, TNF-α and IFN-γ, but not IL-17A, in supernatants of PBMC cultures.?Next, apoptosis induction was addressed by using flow cytometry to evaluate annexin V expression.?Treatment with physalin F (10 μM) increased the apoptotic population of PBMC in HAM/TSP subjects.?Transmission electron microscopy analysis of PBMC showed that physalin F induced ultrastructural changes, such as pyknotic nuclei, damaged mitochondria, enhanced autophagic vacuole formation, and the presence of myelin-like figures.?In conclusion, physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by HTLV-1 infection.
Source	Natural Products > Solanaceae > Physalis

Molecular Weight	526.53
Formula	C28H30O10
CAS No.	57423-71-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (113.95 mM)

References and Literature

1. Pinto L A , Meira, Cássio S, Villarreal C F , et al. Physalin F, a seco-steroid from Physalis angulata L. has immunosuppressive activity in peripheral blood mononuclear cells from patients with HTLV1-associated myelopathy[J]. Biomedicine & Pharmacotherapy, 2016, 79:129-134. 2. Ooi K L , Tengku Muhammad T S , Sulaiman S F . Physalin F from Physalis minima L. triggers apoptosis-based cytotoxic mechanism in T-47D cells through the activation caspase-3- and c-myc-dependent pathways[J]. Journal of Ethnopharmacology, 2013, 150(1):382-388.

Related compound libraries

This product is contained In the following compound libraries：

Anti-virus Traditional Chinese Medicine Monomer Library Human Endogenous Metabolite Compound Library Plus Anti-infective Natural Product Library Covalent Natural Product Library Anti-Tumor Natural Product Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Selected Plant-Sourced Compound Library Traditional Chinese Medicine Monomer Library

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Keywords

physalin F 57423-71-9 Apoptosis cytokine PBMC HTLV-1 infection inflammatory Inhibitor immunomodulatory inhibit proliferation inhibitor

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