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PI3Kα/mTOR-IN-1
🥰Excellent
Catalog No. T12589Cas No. 1013098-90-2
PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR, with an IC50 of 7 nM for PI3Kα in a cell assay and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα [in a cell-free assay], respectively.
PI3Kα/mTOR-IN-1
🥰Excellent
Purity: 99.3%
Catalog No. T12589Cas No. 1013098-90-2
PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR, with an IC50 of 7 nM for PI3Kα in a cell assay and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα [in a cell-free assay], respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $656 | In Stock | |
| 5 mg | $1,290 | In Stock | |
| 10 mg | $1,730 | In Stock | |
| 25 mg | $2,590 | In Stock | |
| 50 mg | $3,480 | In Stock | |
| 100 mg | $4,720 | In Stock |
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Purity:99.3%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR, with an IC50 of 7 nM for PI3Kα in a cell assay and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα [in a cell-free assay], respectively. |
| Targets&IC50 | PI3Kα:12.5 nM (ki), PI3Kα:7 nM (Cell Assay), mTOR:10.6 nM (ki) |
| In vitro | PI3Kα/mTOR-IN-1 exhibited excellent kinase selectivity from Pfizer’s in-house kinase selectivity panel of 43 kinases[1]. |
| In vivo | PI3Kα/mTOR-IN-1 exhibited exhibited moderate clearance, moderate Vdss, T1/2 of 0.9 h, and good oral bioavailability[1]. |
| Molecular Weight | 310.35 |
| Formula | C16H18N6O |
| Cas No. | 1013098-90-2 |
| Smiles | O=C1N(C=2C(C=C1C=3C=NNC3)=C(C)N=C(N)N2)C4CCCC4 |
| Relative Density. | 1.422 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (35.44 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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