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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $656 | In Stock | |
5 mg | $1,290 | In Stock | |
10 mg | $1,730 | In Stock | |
25 mg | $2,590 | In Stock | |
50 mg | $3,480 | In Stock | |
100 mg | $4,720 | In Stock |
Description | PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα in a cell free assay , respectively. |
Targets&IC50 | PI3Kα:7 nM (Cell Assay), mTOR:10.6 nM (ki), PI3Kα:12.5 nM (ki) |
In vitro | PI3Kα/mTOR-IN-1 exhibited excellent kinase selectivity from Pfizer’s in-house kinase selectivity panel of 43 kinases[1]. |
In vivo | PI3Kα/mTOR-IN-1 exhibited exhibited moderate clearance, moderate Vdss, T1/2 of 0.9 h, and good oral bioavailability[1]. |
Molecular Weight | 310.35 |
Formula | C16H18N6O |
Cas No. | 1013098-90-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 11 mg/mL (35.44 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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