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PI4KIIIbeta-IN-9
🥰Excellent
Catalog No. T12469Cas No. 1429624-84-9
PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ [IC50 of 7 nM].
PI4KIIIbeta-IN-9
🥰Excellent
Purity: 97.18%
Catalog No. T12469Cas No. 1429624-84-9
PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ [IC50 of 7 nM].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $73 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $297 | In Stock | |
| 25 mg | $538 | In Stock | |
| 50 mg | $753 | In Stock | |
| 100 mg | $987 | In Stock |
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Purity:97.18%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ [IC50 of 7 nM]. |
| Targets&IC50 | PI4KIIIα:2.6 μM, PI4KIIIβ:7 nM, PI3Kγ:1046 nM, PI3Kα:2 μM, PI3KC2γ:1 μM, PI3Kδ:152 nM |
| In vitro | PI4KIIIbeta-IN-9 (Compound 9) exhibits weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~2 μM), and PI4KIIIα (~2.6 μM), with less than 50% inhibition up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ. It conforms to the active site of PI4KIIIβ, forming extensive contacts, and inhibits PI3Kδ and PI3Kγ with IC50 values of 152 nM and 1046 nM, respectively. |
| Molecular Weight | 487.59 |
| Formula | C23H25N3O5S2 |
| Cas No. | 1429624-84-9 |
| Smiles | COc1ccc(cc1S(=O)(=O)Nc1ccc(O)cc1)-c1sc(NC(=O)C2CCCC2)nc1C |
| Relative Density. | 1.421 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.88 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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